Current fan set up is 2 140 mm Noctua PWM intake fans on a GTX H110i GT and a 140 mm PWM fan as exhaust in a Define S case all mod vents closed. I like quiet.
If I would spring for a ASUS 1080 Strix, Configure the fans with the top 140 connected to the CPU/MB Temps and the bottom one and rear exhaust to the Strix card since it is the highest heat producer in the case.
Keeping the top one on all the time would keep a bit of positive case pressure I would think.
Dose not seem to be much info from users or reviews USING this feature on the web.